Perioperative systemic nonsteroidal anti-inflammatory drugs (NSAIDs) in women undergoing breast surgery
نویسندگان
چکیده
منابع مشابه
Nonsteroidal Anti-inflammatory Drugs (NSAIDs) and Chemoprevention of Breast Cancer
Randall Harris, of Ohio State University, Columbus, Ohio, and colleagues presented very interesting results from a prospective study on the effects of anti-inflammatory agents in the chemoprevention of breast cancer in women enrolled in the Women's Health Initiative observational study. A total of 80,741 postmenopausal women (50-79 years of age) with no previous history of cancer (other than no...
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Nonsteroidal anti-inflammatory drugs (NSAIDs) are a diverse class of drugs commonly used for the treatment of inflammatory conditions, have been found to be highly effective in preventing and treating many types of cancers. However, toxicity from cyclooxygenase (COX) inhibition and the suppression of physiologically important prostaglandins limits their use for cancer chemoprevention and prompt...
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BACKGROUND AND OBJECTIVES Perioperative pain in children can be effectively managed with systemic opioids, but addition of paracetamol or nonsteroidal anti-inflammatory drugs (NSAIDs) may reduce opioid requirements and potentially improve analgesia and/or reduce adverse effects. METHODS A systematic literature search was conducted to identify trials evaluating postoperative opioid requirement...
متن کاملNonsteroidal anti-inflammatory drugs.
Non-steroidal anti-inflammatory drugs (NSAIDs) are usually defined as those agents that inhibit one or more reactions involved in the production of prostaglandins and thromboxanes, important mediators of the inflammatory process in many organs and tissues. They find use in horses in the supportive treatment of a variety of systemic states and painful musculoskeletal or soft tissue conditions. T...
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their fi ndings on NSAID use and breast cancer risk? The answer lies in an appreciation of the likely mechanisms of NSAID-mediated breast cancer suppression. COX enzymes, the primary molecular targets of NSAIDs, synthesize prostaglandins (PGs) from arachidonic acid (13 , 14). COX-1 is normally expressed constitutively, whereas COX-2 is an early-response gene whose expression is increased in res...
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ژورنال
عنوان ژورنال: Cochrane Database of Systematic Reviews
سال: 2019
ISSN: 1465-1858
DOI: 10.1002/14651858.cd013290